NAD+ / MOTS-c / 5-Amino-1MQ (100mg / 10mg / 10mg)
NAD+ / MOTS-c / 5-Amino-1MQ is a triple-compound research blend combining a central redox coenzyme (NAD+), a mitochondrial-derived peptide (MOTS-c), and a small-molecule NNMT inhibitor (5-Amino-1MQ).
Researchers use this combination to study mitochondrial function, cellular energy metabolism, and NAD+-dependent signaling under controlled laboratory conditions.
This compound is provided by GENIQ exclusively for scientific research and not for human or animal use.
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What Is NAD+ / MOTS-c / 5-Amino-1MQ?
NAD+ / MOTS-c / 5-Amino-1MQ is a research blend designed for studies on mitochondrial biology and cellular energy metabolism.
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme central to redox reactions and sirtuin activity. MOTS-c is a 16-amino-acid peptide encoded within mitochondrial DNA that participates in metabolic-stress signaling. 5-Amino-1MQ is a small molecule that inhibits nicotinamide N-methyltransferase (NNMT), an enzyme involved in NAD+ precursor consumption.
Researchers use this blend to investigate how NAD+ availability, mitochondrial signaling, and NNMT inhibition interact in cellular models of energy homeostasis.
GENIQ provides this compound solely for controlled laboratory research, not for human or animal use.
Peptide Overview
This blend merges three compounds commonly used in mitochondrial and metabolic research:
NAD+:
A redox coenzyme studied for its role in electron transport, sirtuin and PARP activity, and cellular energy-metabolism models.
MOTS-c:
A mitochondrial-derived peptide investigated for AMPK-pathway signaling, folate-cycle regulation, and metabolic-stress responses in cellular models.
5-Amino-1MQ:
A selective NNMT inhibitor studied for its influence on NAD+ salvage pathways, methylation balance, and adipocyte metabolism in vitro.
| Laboratory studies evaluate how this compound combination may influence: |
| • NAD+/NADH ratio and sirtuin-dependent signaling |
| • AMPK activation and mitochondrial biogenesis markers |
| • NNMT activity and one-carbon metabolism |
| • Cellular energy-metabolism pathways in preclinical models |
| These findings are strictly from research environments. |
All findings remain limited to preclinical and in-vitro experimental environments.
History of NAD+ / MOTS-c / 5-Amino-1MQ
NAD+ was identified in the early twentieth century as a coenzyme in fermentation and has since become one of the most studied molecules in cellular metabolism, particularly in relation to sirtuin biology and age-related changes in NAD+ levels.
MOTS-c was described in 2015 as a peptide encoded within the mitochondrial 12S rRNA gene, opening a new field of research on mitochondrial-derived peptides and their role in metabolic signaling.
5-Amino-1MQ emerged from medicinal-chemistry programs seeking selective, membrane-permeable NNMT inhibitors. Researchers began combining these three compounds to examine complementary approaches to NAD+ metabolism and mitochondrial function within a single experimental framework.
Peptide Structure
NAD+:
Molecular Formula: C21H27N7O14P2
MOTS-c Sequence:
Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
5-Amino-1MQ:
5-Amino-1-methylquinolinium
Molecular Formula: C10H11N2+
Certificates of Analysis
NAD+ / MOTS-c / 5-Amino-1MQ (100mg / 10mg / 10mg)
Research Findings
Research models analyzing the combined activity of NAD+, MOTS-c, and 5-Amino-1MQ commonly explore:
| • NAD+ metabolism: Measuring changes in NAD+ availability, salvage-pathway flux, and sirtuin activity. |
| • Mitochondrial signaling: Examining MOTS-c-mediated AMPK activation and metabolic-stress responses in cellular models. |
| • NNMT inhibition: Investigating how reduced nicotinamide methylation affects methyl-donor balance and adipocyte metabolism. |
| • Cellular energetics: Assessing oxygen consumption, ATP production, and mitochondrial biogenesis markers in vitro. |
| These data represent controlled in-vitro and preclinical studies, not clinical outcomes. |
These findings reflect laboratory experiments only and do not indicate clinical outcomes.
References
2. Lee C., et al. “The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.” Cell Metabolism, 2015.
3. Reynolds J.C., et al. “MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis.” Nature Communications, 2021.
4. Neelakantan H., et al. “Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice.” Biochemical Pharmacology, 2018.
FAQ
What type of research is this blend used for?
It is used to study NAD+ metabolism, mitochondrial signaling, NNMT inhibition, and cellular energy homeostasis.
Does GENIQ provide a Certificate of Analysis?
Yes. Every GENIQ peptide includes a COA verifying identity and purity.
Is this product approved for human or animal use?
No. It is not FDA-approved and not intended for human or veterinary administration.
Can GENIQ provide instructions regarding preparation or use?
No. GENIQ does not give any guidance related to reconstitution, dosing, or application.
Who should handle this compound?
Only trained laboratory researchers in controlled scientific environments.
Research Use Only
All GENIQ compounds are intended strictly for laboratory research.
Not for human or animal consumption, medical use, or therapeutic application.
Nothing in this document should be interpreted as medical advice or as approval for use outside controlled scientific environments.
NAD+ / MOTS-c / 5-Amino-1MQ is a triple-compound research blend combining a central redox coenzyme (NAD+), a mitochondrial-derived peptide (MOTS-c), and a small-molecule NNMT inhibitor (5-Amino-1MQ).
Researchers use this combination to study mitochondrial function, cellular energy metabolism, and NAD+-dependent signaling under controlled laboratory conditions.
This compound is provided by GENIQ exclusively for scientific research and not for human or animal use.
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